LymphedemaV1, Main, Exploration, bibRecord, 005E90

Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema

Identifieur interne : 005E90 ( Main/Exploration ); précédent : 005E89; suivant : 005E91

Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema

Auteurs : Joseph M. Rutkowski [Suisse] ; Carl Erik Markhus [Norvège] ; Christina C. Gyenge [Norvège] ; Kari Alitalo [Finlande] ; Helge Wiig [Norvège] ; Melody A. Swartz [Suisse]

Source :

The American journal of pathology [ 0002-9440 ] ; 2010.

RBID : Pascal:10-0147598

Descripteurs français

KwdFr :
- Animaux, Collagène (métabolisme), Derme (anatomopathologie), Derme (métabolisme), Derme (physiopathologie), Femelle, Humains, Liquide extracellulaire (métabolisme), Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Modèles animaux de maladie humaine, Mâle, Métabolisme des lipides, Phénomènes biomécaniques, Phénotype, Pression, Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Souris, Souris de lignée C57BL.
MESH :
- anatomopathologie : Derme, Lymphoedème.
- métabolisme : Collagène, Derme, Liquide extracellulaire, Lymphoedème, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiopathologie : Derme, Lymphoedème.
Pascal (Inist)
- Animaux, Femelle, Humains, Lymphoedème, Derme, Modèles animaux de maladie humaine, Mâle, Métabolisme des lipides, Peau, Collagène, Lipide, Dépôt, Phénomènes biomécaniques, Phénotype, Pression, Souris, Souris de lignée C57BL, Tissu, Oedème, Gonflement, Conductivité hydraulique, Animal, Souris, Primaire, Anatomopathologie.

English descriptors

KwdEn :
- Anatomic pathology, Animal, Animals, Biomechanical Phenomena, Collagen, Collagen (metabolism), Deposition, Derm, Dermis (metabolism), Dermis (pathology), Dermis (physiopathology), Disease Models, Animal, Edema, Extracellular Fluid (metabolism), Female, Humans, Hydraulic conductivity, Lipid Metabolism, Lipids, Lymphedema, Lymphedema (metabolism), Lymphedema (pathology), Lymphedema (physiopathology), Male, Mice, Mice, Inbred C57BL, Mouse, Phenotype, Pressure, Primary, Skin, Swelling, Tissue, Vascular Endothelial Growth Factor Receptor-3 (metabolism).
MESH :
- chemical , metabolism : Collagen, Vascular Endothelial Growth Factor Receptor-3.
- metabolism : Dermis, Extracellular Fluid, Lymphedema.
- pathology : Dermis, Lymphedema.
- physiopathology : Dermis, Lymphedema.
- Animals, Biomechanical Phenomena, Disease Models, Animal, Female, Humans, Lipid Metabolism, Male, Mice, Mice, Inbred C57BL, Phenotype, Pressure.

Abstract

Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mouse and the K14-VEGFR-3-Ig mouse, both lack dermal lymphatic capillaries and exhibit a lymphedematous phenotype attributable to disrupted VEGFR-3 signaling. Here we show that the differences in edematous tissue composition between these two models correlated with drastic differences in hydraulic conductivity. The skin of Chy mice possessed significantly higher levels of collagen and fat, whereas K14-VEGFR-3-Ig mouse skin composition was relatively normal, as compared with their respective wild-type controls. Functionally, this resulted in a greatly increased dermal hydraulic conductivity in K14-VEGFR3-Ig, but not Chy, mice. Our data suggest that lymphedema associated with increased collagen and lipid accumulation counteracts an increased hydraulic conductivity associated with dermal swelling, which in turn further limits interstitial transport and swelling. Without lipid and collagen accumulation, hydraulic conductivity is increased and overall swelling is minimized. These opposing tissue responses to primary lymphedema imply that tissue remodeling- predominantly collagen and fat deposition-may dictate tissue swelling and govern interstitial transport in lymphedema.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832135

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term>
<term>Animal</term>
<term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Collagen</term>
<term>Collagen (metabolism)</term>
<term>Deposition</term>
<term>Derm</term>
<term>Dermis (metabolism)</term>
<term>Dermis (pathology)</term>
<term>Dermis (physiopathology)</term>
<term>Disease Models, Animal</term>
<term>Edema</term>
<term>Extracellular Fluid (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Hydraulic conductivity</term>
<term>Lipid Metabolism</term>
<term>Lipids</term>
<term>Lymphedema</term>
<term>Lymphedema (metabolism)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mouse</term>
<term>Phenotype</term>
<term>Pressure</term>
<term>Primary</term>
<term>Skin</term>
<term>Swelling</term>
<term>Tissue</term>
<term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Collagène (métabolisme)</term>
<term>Derme (anatomopathologie)</term>
<term>Derme (métabolisme)</term>
<term>Derme (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Liquide extracellulaire (métabolisme)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (métabolisme)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Métabolisme des lipides</term>
<term>Phénomènes biomécaniques</term>
<term>Phénotype</term>
<term>Pression</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen</term>
<term>Vascular Endothelial Growth Factor Receptor-3</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Derme</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dermis</term>
<term>Extracellular Fluid</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagène</term>
<term>Derme</term>
<term>Liquide extracellulaire</term>
<term>Lymphoedème</term>
<term>Récepteur-3 au facteur croissance endothéliale vasculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dermis</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Derme</term>
<term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dermis</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biomechanical Phenomena</term>
<term>Disease Models, Animal</term>
<term>Female</term>
<term>Humans</term>
<term>Lipid Metabolism</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Phenotype</term>
<term>Pressure</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Derme</term>
<term>Modèles animaux de maladie humaine</term>
<term>Mâle</term>
<term>Métabolisme des lipides</term>
<term>Peau</term>
<term>Collagène</term>
<term>Lipide</term>
<term>Dépôt</term>
<term>Phénomènes biomécaniques</term>
<term>Phénotype</term>
<term>Pression</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Tissu</term>
<term>Oedème</term>
<term>Gonflement</term>
<term>Conductivité hydraulique</term>
<term>Animal</term>
<term>Souris</term>
<term>Primaire</term>
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<front><div type="abstract" xml:lang="en">Primary lymphedema is a congenital pathology of dysfunctional lymphatic drainage characterized by swelling of the limbs, thickening of the dermis, and fluid and lipid accumulation in the underlying tissue. Two mouse models of primary lymphedema, the Chy mouse and the K14-VEGFR-3-Ig mouse, both lack dermal lymphatic capillaries and exhibit a lymphedematous phenotype attributable to disrupted VEGFR-3 signaling. Here we show that the differences in edematous tissue composition between these two models correlated with drastic differences in hydraulic conductivity. The skin of Chy mice possessed significantly higher levels of collagen and fat, whereas K14-VEGFR-3-Ig mouse skin composition was relatively normal, as compared with their respective wild-type controls. Functionally, this resulted in a greatly increased dermal hydraulic conductivity in K14-VEGFR3-Ig, but not Chy, mice. Our data suggest that lymphedema associated with increased collagen and lipid accumulation counteracts an increased hydraulic conductivity associated with dermal swelling, which in turn further limits interstitial transport and swelling. Without lipid and collagen accumulation, hydraulic conductivity is increased and overall swelling is minimized. These opposing tissue responses to primary lymphedema imply that tissue remodeling- predominantly collagen and fat deposition-may dictate tissue swelling and govern interstitial transport in lymphedema.</div>
</front>
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<affiliations><list><country><li>Finlande</li>
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<name sortKey="Gyenge, Christina C" sort="Gyenge, Christina C" uniqKey="Gyenge C" first="Christina C." last="Gyenge">Christina C. Gyenge</name>
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</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
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Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema

Dermal Collagen and Lipid Deposition Correlate with Tissue Swelling and Hydraulic Conductivity in Murine Primary Lymphedema

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	Serveur d'exploration sur le lymphœdème
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